Like everyone else said, it's unlikely and even if it does, it'll be slow. I ODed on Excedrin before which also has the main core ingredient, Acemetaphine, just not with suicidal intentions. It was an impulse thing and it was miserable! (Still would do it again because it's a great laxative…….) You're just stuck feeling nauseous and lightheaded without being able to properly puke or pass out and even when you do, you feel like you're about to shit yourself.