Just wanted to boost this thread. Why is propofol not more discussed ? I've found a link on russian clearnet but I think it's a scam
It's effect lasts for 5-10 minutes, normal IV injections are unlikely to work no matter what to summarise everything i'm about to yap about
Michael jackson accidentally died of a propofol overdose but he was connected to a IV infusion device, most people here don't know how to use needles and set up cannulas and IV infusion devices, creating a setup for this method is very difficult and convoluted and technical, people rarely study pharmacology and pharmacokinetics, that's why these methods are rarely brought up, and if you could get propofol OTC like that and you have the skills to set it up and configure a IV infusion device to pump stuff at a good pace to sustain CNS depression until apnea and respitatory arrest occurs you'd probably be able to find other GABA-A agonists with better duration of action
It just won't work with a syringe or a needle, it can't contain 1000mg of propofol in one syringe or needle and even if it does you'll never inject it in time before falling unconscious, the concentations are usually 10mg propofol per 1 milileter (1000mg propofol = 100 ml)
It's not impossible to circumvent this if you know how to synthesize propofol and emulsify and sterilize it (synthesized propofol is highly lipid, needs to be emulsified otherwise you're trying to inject a rock into your vein, it won't work otherwise), if you can do this then you could get a molecule with your own rules, like 10ml/1 gram, theorically, you can inject it all before losing consciousness if you do it perfectly or practise beforehand, but so long as propofol's duration of action is 5-10 minutes, there are still a few hurdles you have to pass now that you've pulled off the impossible and injected 1 gram of propofol intravenously before losing consciousness
If it goes perfectly in this scenario (a simple and quick needle injection) and you immediately go into deep CNS depression to the extent apnea happens almost immediately, and the molecule holds up for 10 minutes, then keep in mind permanent brain damage starts only after 4 minutes without oxygen and death can occur as soon as 4 to 6 minutes later if apnea is consistent,
you can end up vegetative if it fails, and brain damage will always happen in this scenario should propofol's duration of action betray you
This method is unpractical for normal people, high skill in execution and very complex in proper set-ups that can work, i don't think anyone other than healthcare professionals who know how to hit a good, set up a cannula and a IV infusion device properly, could really pull it off in real life, and even if they could they'd be smart enough to realise how difficult it is to pull off and know the risks of trusting your fate to a short duration of action drug if your setup was flawed
