Opioid Megathread & Overview

[Rhizomorph1]

hey keeping these in mind, would it be ok to ask for advice? im 43kg (94lbs) and have like upwards of 500mg total of oxycodone (bought from pharmacy myself with a prescription).. do you think this would be a non-method/failed attempt? i have no opioid tolerance or anything of the sort..

I can't speak to that unfortunately as there's too many variables.

At best, google coroners report data and toxicology information. Then you would want to dose markedly higher than the toxic dose. Still, you'll probably just vomit or if using another ROA, your likelihood of dying is only moderate.

You're more likely to survive with a traumatic brain injury if I had to guess. But if you want to attempt this method that's the best information I can provide.

 

[NaiveRealist]

If you use benzos orally to potentiate the opioids taken via IV, how best to time this?

As I understand it, if you IV the opioids right after taking the benzos, you might vomit up the benzos before they are fully absorbed.

However, if you wait too long for the benzos to be absorbed, you run the risk of being too incapacitated to perform the IV injection.

Surely the timing depends on the onset of action of the benzo (or other potentiating drug) you're taking. Take diazepam for example. According to psychonautwiki, diazepam has an onset of 20 to 40 minutes. Given this, should you then wait, say, 10 minutes after taking the diazepam to do the IV? Would you then still risk vomiting the benzos before they're absorbed?

 

[Rhizomorph1]

If you use benzos orally to potentiate the opioids taken via IV, how best to time this?

As I understand it, if you IV the opioids right after taking the benzos, you might vomit up the benzos before they are fully absorbed.

However, if you wait too long for the benzos to be absorbed, you run the risk of being too incapacitated to perform the IV injection.

Surely the timing depends on the onset of action of the benzo (or other potentiating drug) you're taking. Take diazepam for example. According to psychonautwiki, diazepam has an onset of 20 to 40 minutes. Given this, should you then wait, say, 10 minutes after taking the diazepam to do the IV? Would you then still risk vomiting the benzos before they're absorbed?

Your odds of vomiting after a large dose of opioids (especially toxic doses needed to ctb), is almost guaranteed; removing any stomach contents including the benzos if taken orally. I can't advise on the time frame as it probably won't make a huge difference and this is why I recommend people rely on just using a sufficient dose of opioid from the get go. You can potentiate toxicity with a benzo if you wish, but I would never encourage anyone to rely on the potentiation for toxicity.

I always feel the need to remind that even with opioids alone the reliability is moderate and risk of brain injury is high so I still encourage other more reliable methods if ctb is absolutely the only option (I.e., MAID, or the swiss option, etc. have been ruled out)

hey keeping these in mind, would it be ok to ask for advice? im 43kg (94lbs) and have like upwards of 500mg total of oxycodone (bought from pharmacy myself with a prescription).. do you think this would be a non-method/failed attempt? i have no opioid tolerance or anything of the sort..

also good to keep in mind that tolerance is not just from past drug use. People have genetic tolerances too which cause our baseline tolerance to vary a lot too. Other genes can result in more proclivity to vomit, more enzymes which aid in eliminating the drug from the system, or protective pathways which simply reduce the pharmacodynamic effect on respiration (which is what kills you).

Opioids are notoriously prone to large pharmacological differences across individuals because unlike SN which reliably displaces hemoglobin in all people's blood equivocally, opioids produce the effect downstream from a more complex cascade of events which are each susceptible to differences in our biology; hindering or increasing the toxicity depending on the person.

The body has more built-in metabolic protection against downstream opioid-induced asphyxiation than it does against something as direct as hemoglobinemia (how SN kills people) for example.