Discussion Medication/Substance Thread

[MatiSendiri]

Daily bump for today (2)

 

[internallydeceased]

Hi, I'm a pharmacy student and I'd like to answer your question about medication or substance. Ask anything really, and I answer it. I would also try as much as possible to post the source of my answer so you can explore more about that.

Why would I do this? Idk tbh. I was just bored and maybe I can help people in here. I'm also suffering from depression and still on my meds rn. There's definitely times when I feel really suicidal but situation has put me better rn.

If there's any professional here that'll notice that my answer is wrong, please correct it. I don't mind really. That's all, can't wait for your question.

I can obtain 100 10 mg oxycodone hydrochloride and I have 30 mg of Ativan. How much of this do I take to successfully ctb.

 

[RoseGirl]

How much estrogen would i need to inject into my veins to kill me.

How much testosterone would I need to inject into my veins to kill me

 

[tapetum_lucidum]

How much estrogen would i need to inject into my veins to kill me.

we

 

[RoseGirl]

we

us

 

[R. A.]

I can obtain 100 10 mg oxycodone hydrochloride and I have 30 mg of Ativan. How much of this do I take to successfully ctb.

I'm borderline spamming but you posting feels like a momentous occasion:

 

[internallydeceased]

I'm borderline spamming but you posting feels like a momentous occasion:

View attachment 177425

Just ready to go now yk?

 

[MatiSendiri]

I can obtain 100 10 mg oxycodone hydrochloride and I have 30 mg of Ativan. How much of this do I take to successfully ctb

Here's data safety sheet about oxycodone:

https://cdn.pfizer.com/pfizercom/products/material_safety_data/PZ01694.pdf

Lethal dose 50% (LD50) for oxycodone in mouse with oral intake is 482 mg/kg. Now if we use transferring method (mentioned here https://pmc.ncbi.nlm.nih.gov/articles/PMC4804402/), we can found that human equivalent dose (HED) for that is:
HED (mg / kg = 482 × 0.081 (mouse to human transition dose) = 39.042 mg / kg.

Same as ativan (lorazepam), here's the data safety sheet:

https://cdn.pfizer.com/pfizercom/products/material_safety_data/WP00036.pdf

Lethal dose 50% (LD50) for lorazepam in mouse with oral intake is 1850 mg/kg. Now if we use the same transferring method, we can found that human equivalent dose (HED) for that is:
HED (mg / kg = 1850 × 0.081 = 149.85 mg / kg.


Now you can multiply that with your bodyweight and that's how much you should take. For instance, if you have 75 kg bodyweight you should take oxycodone around 2928,15 mg of oxycodone and/or 11238,75 mg of lorazepam. Since your stock of Ativan isn't near enough as needed, I'd suggest focus on oxycodone by stocking them up first. Now do note:
1. These are only calculation. In my opinion, the dose needed to ctb would be way lower than the predicted dose by animals. Even in the calculation paper they included notes that larger animals need far lower dose to achieve the same effect due to larger differences in the physiological process.
2. These are lethal dose 50%, meaning at that dose only 50% of the population of the samples died after ingesting the substance. Same as the transitioned dose. You could be in the upper half or lower half of the 50%. Same as many others, you should try your tolerance with the drug before you truly want to ctb
3. I think your ativan might be useful for you to turn off your SI and not as ctb method. Focus your method on oxycodone since you have bigger stocks of it.

Tldr: Use ativan, wait for it to slowly take effect, then ctb using all of your oxycodone stocks (if you can). Remember to prepare it thoroughly.

How much estrogen would i need to inject into my veins to kill me.

Here's the estrogen data safety sheet:

https://cdn.pfizer.com/pfizercom/products/material_safety_data/MENEST(esterified_estrogen)tablets_30-Jan-2017pdf.pdf

LD50 for mouse in intravenous injection is 1740 mg/kg. With the same calculation as above, we can extrapolate them by this:

HED (mg / kg = 1740 × 0.081 = 140.94 mg / kg.

Same notes as above, but do note ctb by estrogen is pretty rare and unheard of. Here's a case report of similar style if you're interested:

Pulmonary embolism due to exogenous estrogen intoxication - PubMed

We know that exogenous estrogen increase the risk of venous thromboembolism in therapeutic use. It should be kept in mind that even single ingestion of a single high-dose exogenous estrogen intake may induce pulmonary thromboembolism.

pubmed.ncbi.nlm.nih.gov

we

Sorry for not searching enough on testosterone. Data regarding testosterone toxicity is actually far harder to search than estrogen (don't ask me why lmao idk either). Here's one:

https://www.sigmaaldrich.com/ID/en/sds/SIGMA/T1500?userType=undefined

In there they found LD50 for mouse with dermal injection is around 2000 mg/kg. With the same calculation we can make it's HED by:
HED (mg / kg = 2000 × 0.081 = 162 mg / kg.

Now do note that this calculation is extremely flimsy due to:
1. Its only made by using analogies related to the similar compound 4-Androstene-3,17-dione.
2. Still no case report of testosterone being used in ctb
3. The route is dermal injection, not straight up intravenous injection like in estrogen
4. All the points above about LD50 and precaution that this is only a calculation/speculation

we

Sorry for not searching enough on testosterone. Data regarding testosterone toxicity is actually far harder to search than estrogen (don't ask me why lmao idk either). Here's one:

https://www.sigmaaldrich.com/ID/en/sds/SIGMA/T1500?userType=undefined

In there they found LD50 for mouse with dermal injection is around 2000 mg/kg. With the same calculation we can make it's HED by:
HED (mg / kg = 2000 × 0.081 = 162 mg / kg.

Now do note that this calculation is extremely flimsy due to:
1. Its only made by using analogies related to the similar compound 4-Androstene-3,17-dione.
2. Still no case report of testosterone being used in ctb
3. The route is dermal injection, not straight up intravenous injection like in estrogen
4. All the points above about LD50 and precaution that this is only a calculation/speculation

 

[RoseGirl]

What does hed mean?

 

[Freedombus'25]

Daily bump for today!

Can I PM you some questions regarding meds and such. I don't really feel comfy asking in public thread. No pressure or anything....

 

[MatiSendiri]

What does hed mean?

Human equivalent dose. Since studies on toxicology can't be done on humans (obviously), the dose acquired from test animals need to be adjusted to the human level.

Can I PM you some questions regarding meds and such. I don't really feel comfy asking in public thread. No pressure or anything....

Sure, why not? My DM are open.

 

[aspecialappearance]

What is your knowledge on a baclofen overdose? What is does, what it's like, and if it can actually work? I plan on consuming guanfacine as well.