It's said you can find Nembutal at Mexico vets but how do you get it out (Canada.)

[paulf123]

Isn't there a high chance of customs seizure? Thanks.

 

[badatparties]

If you have to ask this question, you probably shouldn't attempt it.

 

[paulf123]

Not sure what you are saying. Do the people that go there CTB then?

 

[badatparties]

Not sure what you are saying. Do the people that go there CTB then?

Some do, some don't. Some take the risk of carrying it in their luggage, and hope the x ray scanners at the airport don't trigger any alarms.

 

[badatparties]

you can synthesize it

Trust me, no you can't.

 

[black money boys]

Trust me, no you can't.

YES, YES YOU CAN.

 

[badatparties]

YES, YES YOU CAN.

Please enlighten me on how you plan to do that.

 

[black money boys]

Please enlighten me on how you plan to do that.

i will respond with the instructions soon just you wait and see

 

[badatparties]

i will respond with the instructions soon just you wait and see

I'll await your AI generated slop instructions that will get you blown up.

 

[WhiteRabbit]

i will respond with the instructions soon just you wait and see

Ok Walter White

 

[black money boys]

I'll await your AI generated slop instructions that will get you blown up.

Making Pentobarbital

Objective: Synthesis of 5-Ethyl-5-(1-methylbutyl)barbituric acid (Pentobarbital) via the "malonic ester" route.

Required materials and equipment:

Key Chemical Reagents:
1. Diethyl malonate (primary starting material)
2. Sodium metal or sodium ethoxide (base)
3. Absolute ethanol
4. 1-Bromopentane
5. Bromoethane
6. Urea
7. Hydrochloric acid
8 Solvents for extraction & purification: Diethyl ether, water, ethanol for recrystallization.

Equipment:
1. Three-neck round-bottom flasks with stir bars
2. Reflux condensers, addition funnels (pressure-equalizing)
3. Heating mantles with precise temperature control
4. Nitrogen/argon gas supply and inlet adapters for inert atmosphere
5. Separatory funnels, rotary evaporator
6. Büchner funnel and vacuum filtration setup
7. Melting point apparatus
8. (Optional, highly recommended) Access to analytical instruments: TLC plates, NMR, IR spectrometer, HPLC

Procedure:

Step 1: Formation of Sodium Diethyl Malonate Enolate

1. In a flame-dried three-neck flask under inert atmosphere, add absolute ethanol.
2. Carefully add clean sodium metal in small pieces until reaction stops, forming sodium ethoxide. Alternatively, use pre made sodium ethoxide.
3. Cool the mixture to 0-5°C (ice bath). Slowly add diethyl malonate while stirring vigorously.

Step 2: First Alkylation

1. Maintain the temperature below 10°C. Slowly add 1-bromopentane via addition funnel over 30-60 minutes.
2. After addition, slowly warm to room temperature, then heat under reflux (approx. 80°C) for 6-12 hours. Monitor reaction progress by TLC.
3. Cool, carefully quench with dilute acid, extract with ether, wash organic layer (water, brine), dry, and concentrate to obtain diethyl malonate.

Step 3: Second Alkylation

1. Repeat Step 1 with the product from Step 2 to generate its sodium enolate.
2. Alkylate with bromoethane using the same controlled procedure (slow addition, low temperature, then reflux).
3.Work up as before to obtain diethyl 5-ethyl-5-(1-methylbutyl)malonate.

Step 4: Cyclization to Form Barbiturate Ring

1. Dissolve the dialkylated malonate ester in absolute ethanol.
2. Add a molar amount of urea and a very small amount of sodium ethoxide.
3. Heat under vigorous reflux for 8-15 hours. The reaction produces pentobarbital sodium salt in solution.
4. Cool, carefully acidify with concentrated HCl to precipitate the free acid (pentobarbital).

Step 5: Purification & Analysis

1. Collect the crude solid via vacuum filtration. Wash thoroughly with cold water, then cold ether.
2. Recrystallize multiple times from a suitable solvent system (ethanol/water, toluene) until constant melting point is achieved. Pure pentobarbital melts at 162-164°C.

 

[intr0verse]

Making Pentobarbital

Objective: Synthesis of 5-Ethyl-5-(1-methylbutyl)barbituric acid (Pentobarbital) via the "malonic ester" route.

Required materials and equipment:

Key Chemical Reagents:
1. Diethyl malonate (primary starting material)
2. Sodium metal or sodium ethoxide (base)
3. Absolute ethanol
4. 1-Bromopentane
5. Bromoethane
6. Urea
7. Hydrochloric acid
8 Solvents for extraction & purification: Diethyl ether, water, ethanol for recrystallization.

Equipment:
1. Three-neck round-bottom flasks with stir bars
2. Reflux condensers, addition funnels (pressure-equalizing)
3. Heating mantles with precise temperature control
4. Nitrogen/argon gas supply and inlet adapters for inert atmosphere
5. Separatory funnels, rotary evaporator
6. Büchner funnel and vacuum filtration setup
7. Melting point apparatus
8. (Optional, highly recommended) Access to analytical instruments: TLC plates, NMR, IR spectrometer, HPLC

Procedure:

Step 1: Formation of Sodium Diethyl Malonate Enolate

1. In a flame-dried three-neck flask under inert atmosphere, add absolute ethanol.
2. Carefully add clean sodium metal in small pieces until reaction stops, forming sodium ethoxide. Alternatively, use pre made sodium ethoxide.
3. Cool the mixture to 0-5°C (ice bath). Slowly add diethyl malonate while stirring vigorously.

Step 2: First Alkylation

1. Maintain the temperature below 10°C. Slowly add 1-bromopentane via addition funnel over 30-60 minutes.
2. After addition, slowly warm to room temperature, then heat under reflux (approx. 80°C) for 6-12 hours. Monitor reaction progress by TLC.
3. Cool, carefully quench with dilute acid, extract with ether, wash organic layer (water, brine), dry, and concentrate to obtain diethyl malonate.

Step 3: Second Alkylation

1. Repeat Step 1 with the product from Step 2 to generate its sodium enolate.
2. Alkylate with bromoethane using the same controlled procedure (slow addition, low temperature, then reflux).
3.Work up as before to obtain diethyl 5-ethyl-5-(1-methylbutyl)malonate.

Step 4: Cyclization to Form Barbiturate Ring

1. Dissolve the dialkylated malonate ester in absolute ethanol.
2. Add a molar amount of urea and a very small amount of sodium ethoxide.
3. Heat under vigorous reflux for 8-15 hours. The reaction produces pentobarbital sodium salt in solution.
4. Cool, carefully acidify with concentrated HCl to precipitate the free acid (pentobarbital).

Step 5: Purification & Analysis

1. Collect the crude solid via vacuum filtration. Wash thoroughly with cold water, then cold ether.
2. Recrystallize multiple times from a suitable solvent system (ethanol/water, toluene) until constant melting point is achieved. Pure pentobarbital melts at 162-164°C.

After 4.3 you'll only need to extract the pentobarbital sodium from solution. No need to acidify to get the free acid pentobarbital.

 

[U. A.]

Cause everyone's got access to a chemistry lab, lol

 

[badatparties]

Making Pentobarbital

Objective: Synthesis of 5-Ethyl-5-(1-methylbutyl)barbituric acid (Pentobarbital) via the "malonic ester" route.

Required materials and equipment:

Key Chemical Reagents:
1. Diethyl malonate (primary starting material)
2. Sodium metal or sodium ethoxide (base)
3. Absolute ethanol
4. 1-Bromopentane
5. Bromoethane
6. Urea
7. Hydrochloric acid
8 Solvents for extraction & purification: Diethyl ether, water, ethanol for recrystallization.

Equipment:
1. Three-neck round-bottom flasks with stir bars
2. Reflux condensers, addition funnels (pressure-equalizing)
3. Heating mantles with precise temperature control
4. Nitrogen/argon gas supply and inlet adapters for inert atmosphere
5. Separatory funnels, rotary evaporator
6. Büchner funnel and vacuum filtration setup
7. Melting point apparatus
8. (Optional, highly recommended) Access to analytical instruments: TLC plates, NMR, IR spectrometer, HPLC

Procedure:

Step 1: Formation of Sodium Diethyl Malonate Enolate

1. In a flame-dried three-neck flask under inert atmosphere, add absolute ethanol.
2. Carefully add clean sodium metal in small pieces until reaction stops, forming sodium ethoxide. Alternatively, use pre made sodium ethoxide.
3. Cool the mixture to 0-5°C (ice bath). Slowly add diethyl malonate while stirring vigorously.

Step 2: First Alkylation

1. Maintain the temperature below 10°C. Slowly add 1-bromopentane via addition funnel over 30-60 minutes.
2. After addition, slowly warm to room temperature, then heat under reflux (approx. 80°C) for 6-12 hours. Monitor reaction progress by TLC.
3. Cool, carefully quench with dilute acid, extract with ether, wash organic layer (water, brine), dry, and concentrate to obtain diethyl malonate.

Step 3: Second Alkylation

1. Repeat Step 1 with the product from Step 2 to generate its sodium enolate.
2. Alkylate with bromoethane using the same controlled procedure (slow addition, low temperature, then reflux).
3.Work up as before to obtain diethyl 5-ethyl-5-(1-methylbutyl)malonate.

Step 4: Cyclization to Form Barbiturate Ring

1. Dissolve the dialkylated malonate ester in absolute ethanol.
2. Add a molar amount of urea and a very small amount of sodium ethoxide.
3. Heat under vigorous reflux for 8-15 hours. The reaction produces pentobarbital sodium salt in solution.
4. Cool, carefully acidify with concentrated HCl to precipitate the free acid (pentobarbital).

Step 5: Purification & Analysis

1. Collect the crude solid via vacuum filtration. Wash thoroughly with cold water, then cold ether.
2. Recrystallize multiple times from a suitable solvent system (ethanol/water, toluene) until constant melting point is achieved. Pure pentobarbital melts at 162-164°C.

This is completely wrong. I will not go into specifics. You have absolutely no idea what you're doing, and copy pasted complete AI slop like i suspected.

Does it say you're 19 on your profile?

 

[black money boys]

This is completely wrong. I will not go into specifics. You have absolutely no idea what you're doing, and copy pasted complete AI slop like i suspected.

Does it say you're 19 on your profile?

"AI slop"









you're insufferable

 

[badatparties]

"AI slop"









you're insufferable

You suggested an NMR spectrometer, something that costs a minimum of $35,000, as a highly recommended piece of kit for a basic organic chemistry synthesis.

Not to mention all the other extremely expensive unnecessary equipment. That should make everyone here laugh their ass off. You copy paste AI write up, and attempt to look cool while spreading horrible misinformation is just sad dude.

Hopefully you grow out of this stage later in life.

 

[WakingNightmare]

Making Pentobarbital

Objective: Synthesis of 5-Ethyl-5-(1-methylbutyl)barbituric acid (Pentobarbital) via the "malonic ester" route.

Required materials and equipment:

Key Chemical Reagents:
1. Diethyl malonate (primary starting material)
2. Sodium metal or sodium ethoxide (base)
3. Absolute ethanol
4. 1-Bromopentane
5. Bromoethane
6. Urea
7. Hydrochloric acid
8 Solvents for extraction & purification: Diethyl ether, water, ethanol for recrystallization.

Equipment:
1. Three-neck round-bottom flasks with stir bars
2. Reflux condensers, addition funnels (pressure-equalizing)
3. Heating mantles with precise temperature control
4. Nitrogen/argon gas supply and inlet adapters for inert atmosphere
5. Separatory funnels, rotary evaporator
6. Büchner funnel and vacuum filtration setup
7. Melting point apparatus
8. (Optional, highly recommended) Access to analytical instruments: TLC plates, NMR, IR spectrometer, HPLC

Procedure:

Step 1: Formation of Sodium Diethyl Malonate Enolate

1. In a flame-dried three-neck flask under inert atmosphere, add absolute ethanol.
2. Carefully add clean sodium metal in small pieces until reaction stops, forming sodium ethoxide. Alternatively, use pre made sodium ethoxide.
3. Cool the mixture to 0-5°C (ice bath). Slowly add diethyl malonate while stirring vigorously.

Step 2: First Alkylation

1. Maintain the temperature below 10°C. Slowly add 1-bromopentane via addition funnel over 30-60 minutes.
2. After addition, slowly warm to room temperature, then heat under reflux (approx. 80°C) for 6-12 hours. Monitor reaction progress by TLC.
3. Cool, carefully quench with dilute acid, extract with ether, wash organic layer (water, brine), dry, and concentrate to obtain diethyl malonate.

Step 3: Second Alkylation

1. Repeat Step 1 with the product from Step 2 to generate its sodium enolate.
2. Alkylate with bromoethane using the same controlled procedure (slow addition, low temperature, then reflux).
3.Work up as before to obtain diethyl 5-ethyl-5-(1-methylbutyl)malonate.

Step 4: Cyclization to Form Barbiturate Ring

1. Dissolve the dialkylated malonate ester in absolute ethanol.
2. Add a molar amount of urea and a very small amount of sodium ethoxide.
3. Heat under vigorous reflux for 8-15 hours. The reaction produces pentobarbital sodium salt in solution.
4. Cool, carefully acidify with concentrated HCl to precipitate the free acid (pentobarbital).

Step 5: Purification & Analysis

1. Collect the crude solid via vacuum filtration. Wash thoroughly with cold water, then cold ether.
2. Recrystallize multiple times from a suitable solvent system (ethanol/water, toluene) until constant melting point is achieved. Pure pentobarbital melts at 162-164°C.

If the ai is correct and you need an inert atmosphere you may as well use the nitrogen for yourself

 

[badatparties]

If the ai is correct and you need an inert atmosphere you may as well use the nitrogen for yourself

Thanks for pointing that out. It's a completely garbage AI copy paste that will lead to nothing but brown goo at the bottom of a flask, and possibly an explosion or two.

 

[Tautochrome]

Thanks for pointing that out. It's a completely garbage AI copy paste that will lead to nothing but brown goo at the bottom of a flask, and possibly an explosion or two.

Welp, for best yield inert atmosphere is recommended to keep anhydrous conditions, it helps avoid unwanted side products and danger. For example, sodium metal reacts violently with water or oxygen, so if you plan to make ethoxide yourself, protecting it from these is pretty important

 

[takemetothestars]

It isnt available

 

[badatparties]

Welp, for best yield inert atmosphere is recommended to keep anhydrous conditions, it helps avoid unwanted side products and danger. For example, sodium metal reacts violently with water or oxygen, so if you plan to make ethoxide yourself, protecting it from these is pretty important

Sodium Metal doesn't react violently with oxygen, stop spreading misinformation. There are other ways to keep anhydrous conditions other than filling the entire room with argon/nitrogen, unless you want to kill yourself .

You would know that if you had an inkling of an idea of what you were talking about. Sadly, you're as ignorant as OP and don't realize his entire post is random AI generated garbage.

I'm done explaining things to people on this post, go blow yourselves up, or asphyxiate yourselves.. You've been warned.

 

[Tautochrome]

Sodium Metal doesn't react violently with oxygen, stop spreading misinformation. There are other ways to keep anhydrous conditions other than filling the entire room with argon/nitrogen, unless you want to kill yourself .

You would know that if you had an inkling of an idea of what you were talking about. Sadly, you're as ignorant as OP and don't realize his entire post is random AI generated garbage.

I'm done explaining things to people on this post, go blow yourselves up, or asphyxiate yourselves.. You've been warned.

Brother, I have sodium metal in my cupboard... And you don't need to fill the entire room with nitrogen for inert atmosphere, you could use a glove box or glove bag. I don't get why you're being so defensive instead of contributing.

 

[metfan647]

All this science goes over my head. Where's my meter of rope?

 

[badatparties]

Brother, I have sodium metal in my cupboard... And you don't need to fill the entire room with nitrogen for inert atmosphere, you could use a glove box or glove bag. I don't get why you're being so defensive instead of contributing.

Again, sodium metal doesn't react violently with oxygen, it turns a dull gray due to oxidation. It comes in mineral oil in order to prevent this. A thin oxidized layer when briefly exposed to air is completely normal, and will not prevent you from making sodium ethoxide.

You don't need to go to the extensive, cost prohibitive lengths, of putting it in a inert glove box/bag. It's completely idiotic for your purposes.

I'm defensive because @what, copy pasted completely dangerous, random AI generated garbage directions, and tried to pass them off as his own. His directions will get people hurt. He highly recommended equipment that costs anywhere from $35,000-$150,000 dollars for an intermediate level organic chemistry synthesis. Does that sound like a guy who knows what he's talking about? People doing things like that should be called out. I think i have a right to be a bit miffed.

Best of luck.

 

[black money boys]

Again, sodium metal doesn't react violently with oxygen, it turns a dull gray due to oxidation. It comes in mineral oil in order to prevent this. A thin oxidized layer when briefly exposed to air is completely normal, and will not prevent you from making sodium ethoxide.

You don't need to go to the extensive, cost prohibitive lengths, of putting it in a inert glove box/bag. It's completely idiotic for your purposes.

I'm defensive because @what, copy pasted completely dangerous, random AI generated garbage directions, and tried to pass them off as his own. His directions will get people hurt. He highly recommended equipment that costs anywhere from $35,000-$150,000 dollars for an intermediate level organic chemistry synthesis. Does that sound like a guy who knows what he's talking about? People doing things like that should be called out. I think i have a right to be a bit miffed.

Best of luck.

first of all, you wouldn't respond to my private texts about why you think this is AI, and you wouldn't answer any other question for that matter.

its true that im not the author, the text was written by a chemist as per my request. hes a good friend of mine and i know for a fact he doesnt use AI.

you are not making it clear why you believe this was AI generated,, is it because a component costs 35-150k? or are you just getting this information from out of your ass because i proved you wrong?

its ironic how you laugh at my age, but you fail to take anything seriously and elaborate, if you are apparently older, act like it. you are the immature one

 

[badatparties]

its true that im not the author, the text was written by a chemist as per my request. hes a good friend of mine and i know for a fact he doesnt use AI.

2-bromopentane is used to make pentobarbital, not 1-bromopentane. Not to mention everything else wrong with your post. Your chemist friend can't even get a basic precursor right. And you are a lying jackass who should probably be banned before you inevitably harm others on this site.

 

[Liebestod]

When will people on this site just face the fact that they will never get access to N. LIKE NEVER. Stop coping and buy a gun or a rope.

 

[Tautochrome]

Again, sodium metal doesn't react violently with oxygen, it turns a dull gray due to oxidation. It comes in mineral oil in order to prevent this. A thin oxidized layer when briefly exposed to air is completely normal, and will not prevent you from making sodium ethoxide.

You don't need to go to the extensive, cost prohibitive lengths, of putting it in a inert glove box/bag. It's completely idiotic for your purposes.

I'm defensive because @what, copy pasted completely dangerous, random AI generated garbage directions, and tried to pass them off as his own. His directions will get people hurt. He highly recommended equipment that costs anywhere from $35,000-$150,000 dollars for an intermediate level organic chemistry synthesis. Does that sound like a guy who knows what he's talking about? People doing things like that should be called out. I think i have a right to be a bit miffed.

Best of luck.

I have zero incentive to argue, but let me re-state things for you. Inert atmosphere, especially during the making of ethoxide and the alkylations, would be recommended for best results. We don't want our ester groups to go through random hydrolysis, or unexpected side products to make purification a bigger hassle. I think the cyclization step isn't as delicate. If you don't care too much about the yield loss, you can of course rawdog the whole process or use other methods, nobody will stop you. The level of rigor you wanna apply is up to you. Flame drying, drying tubes with calcium chloride plugs, super dry alcohol, that's more than enough precaution for a small batch to ctb with. But if you do care about the yield and reproducibility, you will likely need some of that inert gas, either for purging your glass or for a glove box.
Sodium metal reacts vigorously with oxygen and violently with water, do you like that phrasing better? It's unlikely things will blow up in your face if you're careful, so yeah, I may have obscured things by grouping the two as a threat when oxygen is a secondary problem.
And people aren't idiots, nobody will set up a lab only to attempt synthesis using an instruction of unknown source. They'll do the research, and I think the more knowledge is out there, the better we can cross-check our methods. If you have any reliable sources, feel free to share

 

[paulf123]

It isnt available

Why are you sure about that, I thought it's well accepted that mex-vets carry.

 

[paulf123]

Since my thread has been somewhat hijacked, I'll link to another thread of my interest :)
https://sanctioned-suicide.net/threads/sodium-pentothal-oral-ingestion.228686/