Taking this question literally and seriously.
What's a curse? Two paths here. First is a Harry Potter type "magic" curse, a changing of energy in a purposeful way that will yield unlikely or even inexplicable outcomes. Second is a curse like in sports, where you have a bad streak and can never seem to get over it even as statistics suggest you SHOULD HAVE by now.
On the first kind, from what I've learned looking into different beliefs, there are two main takeaways I have: (1) there is something real about there being more to our existence than we understand, and (2) anyone who gives you specifics about it and thinks they have answers is full of it.
So we won't be able to lock down what a curse is exactly, be it magical in nature or an unfortunate statistical anomaly.
The prescription is the same. While curses and whatnot may not follow the rules of the universe as we understand them, that doesn't mean logic doesn't still apply.
To break the curse, something has to change. You have to do something differently. And if that doesn't work, you have to do something else differently. Because whatever you are or are not doing right now is not breaking the curse.
It may seem like a cop-out answer, but it's real.