Cross Tolerance Question

[CelestialSky]

I've read some conflicting information regarding cross tolerance with benzos and N. Some say benzos make no difference, others say it can reduce the effects of N. For the last year and a half, I've been on a low dose of diazepam regularly (1-4mg as needed, sometimes 5 days a week and sometimes 1 day a week). It seems to still work for me. But would this have an impact on N's effectiveness? If anyone knows any information, I'd be grateful.

 

[calendulo]

I've read some conflicting information regarding cross tolerance with benzos and N. Some say benzos make no difference, others say it can reduce the effects of N. For the last year and a half, I've been on a low dose of diazepam regularly (1-4mg as needed, sometimes 5 days a week and sometimes 1 day a week). It seems to still work for me. But would this have an impact on N's effectiveness? If anyone knows any information, I'd be grateful.

No it would not have any impact.
N and Diazepam are differents things, all aspects between them are differents.
If you use N, benzo is superfluous.
If you want test analytics, ask me for.

 

[a_strange_day]

it has an impact depending on how much a tolerance you've built as they both act on gaba receptors
read the book "a guide to a self chosen and humane death", there is a whole chapter about cross tolerance

in you case I dont know since your dosage is pretty low, but in mine I definitely have to withdraw form benzos for at least 3 full weeks before taking my N to ensure it doesn't interfere, I've been taking benzodiazepines for 20 years on/off but mostly on and an average daily dose of 7/8 mg lorazepam

 

[calendulo]

it has an impact depending on how much a tolerance you've built as they both act on gaba receptors
read the book "a guide to a self chosen and humane death", there is a whole chapter about cross tolerance

in you case I dont know since your dosage is pretty low, but in mine I definitely have to withdraw form benzos for at least 3 full weeks before taking my N to ensure it doesn't interfere, I've been taking benzodiazepines for 20 years on/off but mostly on and an average daily dose of 7/8 mg lorazepam

Do not get my wrong, please; but tolerate does not exist when you has taken 9 grms of sodium pentobarbitol.
In fact, he does not need use any sort of benzo at all, but if he wants taking benzos too, he can does it. Do not mind.

There is nothing to ensure using 9 grms.

 

[CelestialSky]

it has an impact depending on how much a tolerance you've built as they both act on gaba receptors
read the book "a guide to a self chosen and humane death", there is a whole chapter about cross tolerance

in you case I dont know since your dosage is pretty low, but in mine I definitely have to withdraw form benzos for at least 3 full weeks before taking my N to ensure it doesn't interfere, I've been taking benzodiazepines for 20 years on/off but mostly on and an average daily dose of 7/8 mg lorazepam

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Thank you, that's very helpful info. I really don't fancy withdrawing off them, even though it's a low dose, I feel awful without them. But obviously I don't wanna take a risk. I guess my low dosage might be in my favour, I can try go a week and see how I get on. Planning on ctb in the next couple of weeks so that should be enough time.

 

[Aliaiactaest]

What about cross-tolerance with alcohol?

 

[calendulo]

What about cross-tolerance with alcohol?

It says about alcoholic people that them suffer more convultions and spend more time until reaching the coma.

 

[a_strange_day]

What about cross-tolerance with alcohol?

it's the same, Alcohol, benzos and opioids affects gaba receptors and therefore can slow down the efficiency of barbiturates
but it depends on many factors, how much/how long you've been taking it, what dosage of pentobarbital you're gonna take, etc

I saw an email of P.N where he answers someone that he has seen a lot of people regularly taking heavy doses of benzodiazepines or/and Opioids dying with a dose of 15g of pentobarbital without making any withdrawal beforehand
but I also saw an email from a well known Swiss organisation saying someone to stop all opioids/painkillers consumption a leat 3 weeks before the final day

I think no one knows for sure, even docs, I asked about it in a lot of places since I'm concerned but I never received a clear answer, no yes or no, just some maybe
and when I say a lot of places I'm talking about professionals people used to deal with it

at the end of the day it's up to you to decide if you want to take the risk or not, personnally I wont and will perform my withdrawal to put all the odds on my side

 

[CelestialSky]

it's the same, Alcohol, benzos and opioids affects gaba receptors and therefore can slow down the efficiency of barbiturates
but it depends on many factors, how much/how long you've been taking it, what dosage of pentobarbital you're gonna take, etc

I saw an email of P.N where he answers someone that he has seen a lot of people regularly taking heavy doses of benzodiazepines or/and Opioids dying with a dose of 15g of pentobarbital without making any withdrawal beforehand
but I also saw an email from a well known Swiss organisation saying someone to stop all opioids/painkillers consumption a leat 3 weeks before the final day

I think no one knows for sure, even docs, I asked about it in a lot of places since I'm concerned but I never received a clear answer, no yes or no, just some maybe
and when I say a lot of places I'm talking about professionals people used to deal with it

at the end of the day it's up to you to decide if you want to take the risk or not, personnally I wont and will perform my withdrawal to put all the odds on my side

Thanks for your reply. I think because of the low dose it's probably okay, but I think I'd rather suffer the withdrawal and have my attempt go successfully - I'm terrified of taking N and waking up.

 

[Aliaiactaest]

If you don't want to screw it up, I would take the max amount of N. and a drink or two of alcohol. As Calendulo says, 12.6g of N and you are not going to wake up. Period. The PPH gives N a 10/10 on reliability, far higher than any other method.