the method is to ferment them in alcohol a while (weeks)
man i just wanted to grab a handful of berries and swallow them out on a nature trial somewhere. i heard that mixing grapefruit juice with antidepressants was deadly. but when i brought that idea to the forum, others said that was horrible and all medication overdoses where terrible and had a high rate of failure.
Combining amitriptyline with grapefruit juice can increase amitriptyline levels in the body, which can lead to serious side effects and toxicity.
thats from one of the papers i posted. ideally, amitriptyline could be then made to interact with phenelzine for the desired death poison effect.
but how to make this stuff from nature... idk, texas is all limestone, cigarette butts, and interstate carbon monoxide....
maybe someday genetic modification technology will be good enough to cross grapefruits with yew berries and make a hideous cross combo that produces enough antihistamines to inhibit CYP3A4 properly. thinking out loud here, but anisoles from inside the yew seeds could be good for the hydroxylation of a ligand in the P450 enzymes.
i mean i doubt it will ever happen, but given that Kenneth Law and all the others that sold sodium nitrite, cyanide, nembutal, etc... are now in jail with life sentences... regular chemicals are hardly an option anymore. Even the great Philip Nitschke has quit... as a serious pro choice man I want to stop talking about it and do something of ACTION... but i dont know anything. I even messed up basic chemical equations with sodium nitrate versus sodium nitrite a few hours ago... because of a one letter SPELLING difference. BUT if this genetically modified grapefruit was made, it would be the next big thing. Law enforcement would never catch it. It would always be under the radar. because all one would have to do is spread the SEEDS around, and seeds themselves are harmless and not illegal. seeds are like an unborn fetus. and society has already banned abortion so why and how could they ban the seeds of a magic death plant.