I've spent the last week experimenting with various amounts of clonazolam. Unfortunately, there is no answer to your question, because everyone reacts so differently to benzos. You have to experiment for yourself and see what works best for you. However, there is definitely a before and after. Dose awhile before the meto/Tagamet, dose again, then dose again after the sn. Just make sure you can stay conscious for 20 moon to make sure you don't puke. Otherwise you will need to redose. You will know that it is working die to the cyanosis. It is asymptomatic so you do not feel a thing. But as your methemoglobin levels reach upwards of 50% you will begin to turn blue. At that point, it should have been about 20 min or so so just take a few more benzos and go to sleep. Should be very peaceful