PursuitofWonder
Student
- Dec 12, 2020
- 137
First off, much love to the community here and what it does for people.
Below is the rather long winded summary of an idea for a Community Effort Project that's been on my mind for quite a while. I would really appreciate y'all reading and giving some feedback if you can!
PAS = Physician Assisted Suicide
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GOALS AND OUTLINE OF COMMUNITY BASED NOVEL MOLECULE DISCOVERY EFFORT
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Goals of Novel Molecule:
A) Maximum Increase in GABA system action
B) Optimal Pharmacokinetics to ensure both recipient comfort and continued efficacy
C) Ease of synthesis and administration
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GENERAL PROJECT BASIS OUTLINE
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The pharmaceutical industry transitioned to purpose based molecular engineering beginning in the mid 20th century, since then the industry has operated on the concept of evidence based molecular design, and later on, mass screening technology. The goal of this idea/project is much the same, however due to the ongoing controversial nature of PAS historically, currently, and almost certainly in the future, there are no molecules specifically designed or selected with this application in mind. Currently used "Gold Standard" drugs used in PAS are primarily sedatives created in the first three decades of the 20th century. These medications were created before the industry transition described above and as such they lack favorable safety profiles and were rapidly replaced by medications purpose made for altered effects, especially a wider therapeutic index, in the 1960s. Indeed it increasingly seems that the very limited areas of the world where PAS is used may lose access to these medications as it is becoming fairly clear that the largest current market for their use is in life ending procedures. Individuals living in areas without PAS or whose condition is not eligible for such measures often use commercially available supplies in an attempt to achieve similar results. This practice results in extremely high amounts of complications for both the individuals health as well as the mental health of those close to them. Additionally, the supplies used effectively by this population can gain more widespread use, eventually ending in commercial restrictions or discontinuation of the product. Ideally a medication designed for life ending properties would only be available to those who are approved for a PAS procedure. Unfortunately the current state of legality and limited acceptance criteria, as well as various social barriers, do not allow that system of distribution to be viable. As such, molecular design and selection must also take into account the potential for self administration, lack of medical monitoring, and lack of certain precursor availability to individual civilians. A group effort by those who support individuals right to end their life could result in a purpose based solution that is effective and prevailing. These outlined factors show a necessity for candidate molecules to be investigated either by funded research, or more likely by qualified private individuals.
Below is the rather long winded summary of an idea for a Community Effort Project that's been on my mind for quite a while. I would really appreciate y'all reading and giving some feedback if you can!
PAS = Physician Assisted Suicide
—————————————————————————
—————————————————————————
GOALS AND OUTLINE OF COMMUNITY BASED NOVEL MOLECULE DISCOVERY EFFORT
————————
Goals of Novel Molecule:
A) Maximum Increase in GABA system action
B) Optimal Pharmacokinetics to ensure both recipient comfort and continued efficacy
C) Ease of synthesis and administration
—————————
GENERAL PROJECT BASIS OUTLINE
—————————
The pharmaceutical industry transitioned to purpose based molecular engineering beginning in the mid 20th century, since then the industry has operated on the concept of evidence based molecular design, and later on, mass screening technology. The goal of this idea/project is much the same, however due to the ongoing controversial nature of PAS historically, currently, and almost certainly in the future, there are no molecules specifically designed or selected with this application in mind. Currently used "Gold Standard" drugs used in PAS are primarily sedatives created in the first three decades of the 20th century. These medications were created before the industry transition described above and as such they lack favorable safety profiles and were rapidly replaced by medications purpose made for altered effects, especially a wider therapeutic index, in the 1960s. Indeed it increasingly seems that the very limited areas of the world where PAS is used may lose access to these medications as it is becoming fairly clear that the largest current market for their use is in life ending procedures. Individuals living in areas without PAS or whose condition is not eligible for such measures often use commercially available supplies in an attempt to achieve similar results. This practice results in extremely high amounts of complications for both the individuals health as well as the mental health of those close to them. Additionally, the supplies used effectively by this population can gain more widespread use, eventually ending in commercial restrictions or discontinuation of the product. Ideally a medication designed for life ending properties would only be available to those who are approved for a PAS procedure. Unfortunately the current state of legality and limited acceptance criteria, as well as various social barriers, do not allow that system of distribution to be viable. As such, molecular design and selection must also take into account the potential for self administration, lack of medical monitoring, and lack of certain precursor availability to individual civilians. A group effort by those who support individuals right to end their life could result in a purpose based solution that is effective and prevailing. These outlined factors show a necessity for candidate molecules to be investigated either by funded research, or more likely by qualified private individuals.
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