do i need meto? or can i just take zofran?, i only have access to zofran

[koalamenace12]

i got zofran, but im wondering if its enough

 

[nymb]

it is not a dopamine receptor agonist. not gonna work very well about vomitting

 

[ferrie]

Zofran can be helpful as it's a 5-HT3 (serotonin) antagonist & there is some serotonin receptor activity associated with GI irritation. It doesn't replace meto though. Meto is a dopamine antagonist, and dopamine receptors are more important when talking about nausea & vomiting from GI irritation. Some people choose to take Zofran as a complement to meto, but Zofran on its own will not be as strong as meto

 

[koalamenace12]

Zofran can be helpful as it's a 5-HT3 (serotonin) antagonist & there is some serotonin receptor activity associated with GI irritation. It doesn't replace meto though. Meto is a dopamine antagonist, and dopamine receptors are more important when talking about nausea & vomiting from GI irritation. Some people choose to take Zofran as a complement to meto, but Zofran on its own will not be as strong as meto

do i have a high chance to fail if i only take zofran

 

[ferrie]

do i have a high chance to fail if i only take zofran

I can't say for certain. Some people succeed without an AE at all. All I know is that you're more likely to vomit if you only take Zofran

 

[koalamenace12]

I can't say for certain. Some people succeed without an AE at all. All I know is that you're more likely to vomit if you only take Zofran

thank you

 

[koalamenace12]

it is not a dopamine receptor agonist. not gonna work very well about vomitting

but it is a sertonin antagonists

 

[nymb]

but it is a sertonin antagonists

dopamine plays a greater role at vomiting and nausea than sertonin, zofran will regulate your nausea but not as much as meto

 

[dying flower]

Zofran can be helpful as it's a 5-HT3 (serotonin) antagonist & there is some serotonin receptor activity associated with GI irritation. It doesn't replace meto though. Meto is a dopamine antagonist, and dopamine receptors are more important when talking about nausea & vomiting from GI irritation. Some people choose to take Zofran as a complement to meto, but Zofran on its own will not be as strong as meto

Do you think that taking Zofran with some thing like ginger would work? It's just that l have read about ginger being some what of an ae

 

[N3UR0T1C]

Zofran is not a dopamine agonist, therefore it will not prevent the poison vomiting reflex. It won't change your chances of success versus just taking no AE.

 

[ferrie]

Do you think that taking Zofran with some thing like ginger would work? It's just that l have read about ginger being some what of an ae

Short answer: Ginger may help with some side effects with nausea, but I don't believe it would have any significant impact on the chances of vomiting with SN. Zofran may have some impact, but it won't be nearly as effective as a dopamine antagonist.

Long answer: Ginger's method of action as an antiemetic isn't direct like a medication like Zofran or meto. It works peripherally to increase gastric tone and motility & may increase gastric emptying. It's anticholinergic and antiserotonergic, but it doesn't work directly on the CTZ. Ginger's great at helping relieve nausea for some people, but from a biological standpoint I don't think it's a strong enough antiemetic to prevent vomiting from severe gastrointestinal tract irritation like what happens with SN. Taking an excessive amount of salt like SN causes GI irritation that then sets off the dopamine receptors of the CTZ which triggers the vomiting reflex, which is why a dopamine antagonist AE is strongly encouraged. Ginger will do nothing to directly counteract this process, so it won't help prevent vomiting. Adding it to Zofran doesn't do anything to increase the effectiveness of either. The best choice at the end of the day is a dopamine antagonist

 

[koalamenace12]

Zofran is not a dopamine agonist, therefore it will not prevent the poison vomiting reflex. It won't change your chances of success versus just taking no AE.

i feel like yall just get on here and say stuff without doing your own research, zofran does help with anti-vomitting, its espeically used in chemotherapy so paitents dont vomit, domapine blockers dont automatically mean the only ones that prevent vomiting, serotionin blockers also has to do with the GI track

 

[N3UR0T1C]

i feel like yall just get on here and say stuff without doing your own research, zofran does help with anti-vomitting, its espeically used in chemotherapy so paitents dont vomit, domapine blockers dont automatically mean the only ones that prevent vommiting

You're the one who came to ask. That suggestion is the culmination of quite a bit of research done on this site by many users. If you think you know better, than disregard everything and do what you want.

 

[koalamenace12]

You're the one who came to ask. That suggestion is the culmination of quite a bit of research done on this site by many users. If you think you know better, than disregard everything and do what you want.

i asked yesterday, got answers and also did my own research, theres even threads on this site, that i found AFTER i posted this about zofran being enough for an AE, some even say the best

 

[nymb]

we dont say it does not gonna work, we trying to say it's not gonna be effective as dopamine receptor agonists

 

[cowboypants]

i got zofran, but im wondering if its enough

Zofran / ondansetron might work on its own.

But see if you can get some kind of OTC dopamine antagonist.

There is a huge thread of what are the alternatives. Combine it with zofran and you are set good.

Most of the dopamine antagonist also seem to help with gastric emptying. Which will increase potentiation of the SN.

 

[koalamenace12]

Zofran / ondansetron might work on its own.

But see if you can get some kind of OTC dopamine antagonist.

There is a huge thread of what are the alternatives. Combine it with zofran and you are set good.

Most of the dopamine antagonist also seem to help with gastric emptying. Which will increase potentiation of the SN.

serotonin antagonists can also help with gastric emptying

 

[_Gollum_]

Ginger's great at helping relieve nausea for some people, but from a biological standpoint I don't think it's a strong enough antiemetic to prevent vomiting from severe gastrointestinal tract irritation like what happens with SN.

Can confirm, I tried to poison myself with a plant fertilizer using ginger as an antiemetic and it was essentially useless, I threw up within 5 minutes.