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Lollypop24

Member
Apr 5, 2022
69
So I plan to overdose on amitriptyline, I have 4.2 grams just arrived today. Does anyone know the actual lethal dose of amitriptyline? I've heard so many answers and it varies from 500mg-1000mg to 8grams. I have olanzapine as an anti-emetic and not much else
 
H

[HNO]

Experienced
Aug 21, 2022
283
"Ld50 on amitriptyline is 140mg per kg. Ld50 means the lethal dose for 50 percent of test subjects (mice). So for someone 70kg. It would take 9800mg. Of amitriptyline for a 50 percent chance of dying."
 
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SofterSoftest

SofterSoftest

Student
Dec 30, 2021
186
There's a whole chapter on amitriptyline in the PPEH (you can download it off here). It goes into great detail about the dose required, the dose of recommended benzos, and even the amount of alcohol you should take with it. What I'm still not sure about is whether the amitriptyline method requires benzos. Virtually all firsthand accounts I've read of amitriptyline OD suggest that you pass out pretty quickly on ami even if you don't take benzos, but then there are people who say they've witnessed others puking or thrashing around on large doses of amitriptyline, so I have no idea.
 
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G

grp35

Member
Sep 22, 2022
37
There's a whole chapter on amitriptyline in the PPEH (you can download it off here). It goes into great detail about the dose required, the dose of recommended benzos, and even the amount of alcohol you should take with it. What I'm still not sure about is whether the amitriptyline method requires benzos. Virtually all firsthand accounts I've read of amitriptyline OD suggest that you pass out pretty quickly on ami even if you don't take benzos, but then there are people who say they've witnessed others puking or thrashing around on large doses of amitriptyline, so I have no idea.
I just got 10g of Ami and am keen to CTB asap. However, this method seems to take a long time and has high survival risk if you are discovered. It also seems likely that you will have severe brain and organ damage if you survive. Also, I'm easy to vomit, and I worry about failing due to getting sick. I don't think the AE will do enough to block my vomiting :-(

Has anyone had any recent experience with Ami? I know squirtsoda took 5.5g and survived but I haven't seen much from anyone else using this method recently.
 
M

MelodyCymbal

Member
Jan 21, 2023
68
So I plan to overdose on amitriptyline, I have 4.2 grams just arrived today. Does anyone know the actual lethal dose of amitriptyline? I've heard so many answers and it varies from 500mg-1000mg to 8grams. I have olanzapine as an anti-emetic and not much else
2023 PPeH says 10 gm
 
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M

MelodyCymbal

Member
Jan 21, 2023
68
So I plan to overdose on amitriptyline, I have 4.2 grams just arrived today. Does anyone know the actual lethal dose of amitriptyline? I've heard so many answers and it varies from 500mg-1000mg to 8grams. I have olanzapine as an anti-emetic and not much else
In addition to the 10 gms of Ami., it's recommended to take a benzo such as Oxazepam 600 mg or Bromazolam 50 mg
 
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S

Sad Bear

GivenUp
Mar 29, 2025
61
Does this method work? I keep hearing of various accounts. It's all I have on hand and really need to CTB.
 

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